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Early works are under way in Lancashire, with the wider $231m project subject to planning and final approval.
The works will add 400 beds and security upgrades, with CPB Contractors delivering the project alongside QCS and DHPW.
The project involves upgrades to existing railway platforms and the construction of two new platforms with associated track works.
Eiffage’s share is valued at €109m ($127m) for Angers University Hospital and nearly €23m ($27m) for Avallon hospital centre.