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The development will deliver nearly 700 homes, new healthcare facilities and expanded public spaces at Elephant and Castle.
The 133,000ft² hospital is scheduled to open by the end of 2028 and will serve more than 260,000 patient visits each year.
The application outlines affordable housing, schools, employment land and public transport links in the development plan.
The company expects to cease production of Rokbak articulated haulers in the second half of 2026.